@article { author = {Shahriari, Sahar and Eftekhari, Mohammad Hasan and Jeddi, Marjan}, title = {The Effect of Vitamin D Supplementation in Overweight or Obese Type 2 Diabetic Patients with Vitamin D Deficiency and Dyslipidemia}, journal = {International Journal of Nutrition Sciences}, volume = {3}, number = {4}, pages = {185-191}, year = {2018}, publisher = {Shiraz University of Medical Sciences}, issn = {2538-1873}, eissn = {2538-2829}, doi = {10.30476/ijns.2019.82643.1021}, abstract = {Background: Vitamin D supplementation was shown to reduce obesityrelated oxidative stress and inflammation among overweight or obese people as well as improving glycemic control and lipid profile in type 2 diabetic (T2D) patients. This study was conducted to determine the effect of vitamin D supplementation on metabolic biomarkers, oxidative stress and systemic inflammation in overweight or obese T2D patients with vitamin D deficiency and dyslipidemia.Methods: In this randomized, double-blind placebo-controlled clinical trial, 60 individuals with T2D, vitamin D deficiency and BMI greater than 25 kg/m2 were randomly divided in two groups to receive either vitamin D (50000 IU, once a week) or placebo (1000 mg corn oil, oncea week) for eight weeks. At the entry and end of study, blood samples were collected to evaluate serum high sensitive C-reactive protein (hs-CRP), fasting blood sugar (FBS), glycated hemoglobin (HbA1c) malondialdehyde (MDA), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triglycerides (TG).Results: At the end of the study, serum FBS (P=0.04), TG (P=0.02) and hs-CRP (P=0.02) levels significantly decreased in the vitamin D supplemented group in comparison to the control group. Supplementation with vitamin D was associated with significant improvements in serum 25 –OH vitamin D levels when compared to the control group.Conclusion: This study indicates that eight weeks supplementation of vitamin D may improve lipid, glycemic and inflammatory indices in overweight or obese T2D patients with vitamin D deficiency and dyslipidemia.}, keywords = {Vitamin D,diabetes mellitus,Dyslipidemia,Obesity,Inflammation}, url = {https://ijns.sums.ac.ir/article_45388.html}, eprint = {https://ijns.sums.ac.ir/article_45388_ba83b3587a35706b92a07be5f1e2eb4a.pdf} }