TY - JOUR ID - 43408 TI - Vitamin E Supplementation and Circulating Adiponectin Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials JO - International Journal of Nutrition Sciences JA - IJNS LA - en SN - 2538-1873 AU - Mohammadi-Sartang, Mohsen AU - Dashtabi, Arash AU - Mazloom, Zohreh AD - Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran AD - Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran Y1 - 2017 PY - 2017 VL - 2 IS - 3 SP - 118 EP - 125 KW - Vitamin E KW - Tocopherols KW - Adipokine KW - Adiponectin DO - N2 - Current results from clinical trials about vitamin E effects on adiponectin are ambiguous. Therefore, we conducted a meta-analysis of available RCTs to resolve this inconsistency. The systematic search was performed in several databases including SCOPUS, PubMed-Medline, and Google Scholar until October 1st, 2017. We used fixedeffects model in combination with mean difference (MD) and 95% confidence intervals (CI) for the analysis of data. Meta-analysis of 6 RCTs (9 treatment arms) showed a significant increase in circulating adiponectin levels (MD: 0.36 ug/ml, 95% CI: 0.16 to 0.56; p <0.001), following vitamin E supplementation. In sub-group analysis, a significant increasing effect was observed only in trials with ≥400 mg/day dosage (MD: 0.78 ug/ml, 95% CI: 0.31, 1.24, p=0.001) and those trials lasting ≥6 months (MD: 0.58 ug/mL, 95% CI: 0.29, 0.86, p <0.001). In meta-regression, there was association between changes in adiponectin concentrations and duration of supplementation. Our findings showed the significant increase effect of vitamin E supplementation on circulating adiponectin levels, however a significant increasing effect was observed at doses above 400 mg/day and when supplementation lasting over 6 months. UR - https://ijns.sums.ac.ir/article_43408.html L1 - https://ijns.sums.ac.ir/article_43408_f76ab6942750c3dcd4905aff8cc8f321.pdf ER -