TY - JOUR ID - 47074 TI - The Effect of Citrullus Colocynthis on Serum Lipid Profile and Hepatic Histology in CCl 4-Induced Liver Injury Rat Model JO - International Journal of Nutrition Sciences JA - IJNS LA - en SN - 2538-1873 AU - Fouzi, Mina AU - Razmi, Nematollah AU - Mehrabani, Davood AD - Department of Biochemistry, Fars Science and Research Branch, Islamic Azad University, Fars, Iran AD - Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Y1 - 2020 PY - 2020 VL - 5 IS - 4 SP - 208 EP - 213 KW - Citrullus colocynthis KW - Lipid profile KW - Fatty liver KW - CCl4 KW - Rat DO - 10.30476/ijns.2020.88244.1094 N2 - Background: Chemical drugs in treatment of liver diseases are still scare and with many complications. Citrullus colocynthis known as bitter apple is on of herbals that can affect liver function. This study evaluated the effect of C. colocynthis on serum lipid profile and hepatic tissue histology in CCl4-induced liver injury rat model.Methods: In this experimental animal study, forty-two Wistar rats were randomly divided into 6 equal groups of control received 1 mL/kg of distilled water, twice a week for 2 weeks intraperitoneally (IP); sham injected with 50% CCl4 identically; and experimental groups administered with just 20 mg/kg of C. colocynthis similarly; receipt of 20 mg/kg of C. colocynthis after induction of fatty liver disease by CCl4, identically; received 50 mg/kg of C. colocynthis in the same manner; and receipt of 50 mg/kg of C. colocynthis after induction of fatty liver disease by CCl4, identically. The triglyceride (TG) and cholesterol levels were determined and liver tissue changes were assessed histologically before and after interventions.Results: C. colocynthis could decrease TG, total cholesterol (TC), highdensity lipoprotein (HDL), but not low-density lipoprotein (LDL) after liver injury. C. colocynthis could significantly ameliorate the injured liver.Conclusion: Based on the decrease in TG, TC and HDL levels and histological healing picture in hepatic tissue after administration of C. colocynthis, it can be recommended as an alternative medical therapy for liver injuries because it is inexpensive and is easily available. These findings can be added to the literature when targeting treatment of liver injuries. UR - https://ijns.sums.ac.ir/article_47074.html L1 - https://ijns.sums.ac.ir/article_47074_4506134aa92fcb0f1602f48f6cd4dcc3.pdf ER -