Shiraz University of Medical SciencesInternational Journal of Nutrition Sciences2538-18734220190601The Effects of Vitamin K Supplementation in Vascular Calcification: A Systematic Review54584493310.30476/ijns.2019.81825.1014ENMaryamSharafi MiabStudent Research Committee, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IranSeyed JalilMassoumiNutrition and Food Sciences Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IranNutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences,
Shiraz, IranSUMS Employees Health Cohort Study, Shiraz University of Medical Sciences, Shiraz, Iran0000-0001-6712-6802NedaHaghighatNutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences,
Shiraz, IranMortezaZareNutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences,
Shiraz, Iran0000-0000-0000-0000Journal Article20180129Background: Vascular calcification is a predictor of cardiovascular morbidity and mortality, which can be evaluated by pulse wave velocity (PWV) and Coronary Artery Calcification score (CAC. s). Vitamin K-dependent matrix Gla protein (MGP) is an important inhibitor of calcification. The aim of this systematic review was to assess the effect of high-dose vitamin k supplementation on vascular calcification. <br /> Methods: In this systematic review, a literature search in PubMed was undertaken with using the keywords “vitamin k1 supplementation” OR “phylomenadion supplementation” OR “vitamin k2 supplementation” OR “menaquinone supplementation” OR “vitamin k3 supplementation” OR “menadion supplementation” and “calcification”, and then qualified articles were used.<br /> Results: Vitamin K1 supplement was not associated with <br /> dephosphorylated-uncarboxylated MGP (dp-uc MGP) level and PWV level. However, it was associated with less CAC progression. Vitim K2 supplement was correlated inversely with dp-uc MGP level and decrease in PWV but no difference CAC progression. <br /> Conclusion: Based on results that was obtained from this systematic review, we expressed conclusively that taking vitamin K supplements especially vitamin K2 can decrease inactive MGP levels and slow the progression of CAC in healthy older adults with pre-existing CAC and improve arterial stiffness.https://ijns.sums.ac.ir/article_44933_0eac00b267d9965f03af6cc8e45269b7.pdfShiraz University of Medical SciencesInternational Journal of Nutrition Sciences2538-18734220190601Glycemic Control and Acne: A Review59644493410.30476/ijns.2019.81827.1016ENZahraSetavandStudent Research Committee, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IranMaryamEkramzadehNutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran0000-0002-7994-8405Journal Article20171216Acne as a chronic inflammation involves pilosebaceous unit and is associated with hyperkeratosis and sebaceous hypersecretion. A high glycemic index (GI) and glycemic load (GL) diet may stimulate acne proliferative pathways affecting biochemical factors in acne. Although GI and GL have a prominent role in acne pathophysiology, few literatures assessed this association. This review was undertaken to summarize the published data regarding the effect of low glycemic load diet on acne lesions. A literature search was conducted in PubMed, Science direct, Google scholar up to January 2019. GI and GL are implicated in acne pathogenesis due to diet-induced hyperinsulinemia, stimulating a rise in IGF-1 concentrations and androgen hormones and as a result, amplifying acne-promoting pathways.https://ijns.sums.ac.ir/article_44934_6b9c0ddd80ad4a7765686e77ce2837f9.pdfShiraz University of Medical SciencesInternational Journal of Nutrition Sciences2538-18734220190601The Effects of Papaya Fruit as Anti Diabetes: A Review65704531210.30476/ijns.2019.81751.1013ENZuhriaIsmawantiDepartment of Clinical Nutrition and Nutrition Sciences, Postgraduate Sebelas Maret University, Surakarta, Indonesia0000-0003-4083-5048Joseph BenedictusSuparyatmoDepartment of Clinical Pathology, Faculty of Medicine Sebelas Maret University, Surakarta, IndonesiaBudiyantiWiboworiniDepartment of Nutrition, Faculty of Medicine Sebelas Maret University, Surakarta, IndonesiaJournal Article20190528Diabetes mellitus (DM) is a disease that results in an imbalance in the body ability to use food efficiently caused by the pancreas failure to produce insulin or dysfunction of the body to use insulin properly. Type 2 DM can cause oxidative stress which results in changes in endogenous antioxidant activity and also an increase in oxidative biomolecular damage. This condition causes patients with type 2 DM to require large amounts of exogenous antioxidant intake to inhibit oxidative damage in the body. One of the medicinal plants that has antihyperglycemic activity and high antioxidants is papaya (Carica papaya Linn). Based on a review of several studies noted that papaya contains vitamin C, fiber saponins and flavonoids that can lower blood glucose levels. However, to prove this effect, further clinical trials are needed to be done.https://ijns.sums.ac.ir/article_45312_854c54f7a8d0e34c3a9823374fc7ec37.pdfShiraz University of Medical SciencesInternational Journal of Nutrition Sciences2538-18734220190601Effect of Zinc Supplementation on Weight and Food Intake in Patients under Hemodialysis71774498510.30476/ijns.2019.81548.1009ENSeyyedeh MaryamSadeghiDepartment of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IranFatemehSadeghiDepartment of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IranMasoumehAkhlaghiNutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran0000-0003-3868-0227Journal Article20180301Background: Poor appetite is one of the nutritional problems of hemodialysis patients. We examined the effect of zinc supplementation on weight and dietary intakes in hemodialysis patients.<br />Methods: In a single-blind randomized clinical trial, 61 hemodialysis patients were recruited and randomly divided into two groups of zinc supplements (capsules containing 50 mg elemental zinc) and control (placebo capsules containing cornstarch). The intervention lasted for 60 days. Thirty-eight patients (17 in zinc supplements and 21 in the<br />placebo group) completed the study. Weight, blood pressure, biochemical parameters including serum calcium, phosphorus, potassium, sodium, blood urine nitrogen, and creatinine were measured and 24-hour food recalls were obtained before and after the intervention.<br />Results: Weight of the subjects in the zinc group increased (2.4, 95% CI: -1.6 to 6.5 kg) and that of the control decreased (-0.85, 95% CI: -2.9 to 1.2 kg) during the intervention. Although none of these alterations was significant, the difference between the two groups was statistically significant. Changes in biochemical parameters and blood pressure were not significantly different between the two groups. The intake of protein (12.7% vs. 8.6% for zinc vs. control), carbohydrate (13.8% vs. 3.0% for zinc vs. control), and energy (8.9% vs. 4.7% for zinc vs. control) increased in both groups, although there was no significant difference between the groups.<br />Conclusion: It was shown that zinc supplementation may increase weight gain and food intake in hemodialysis patients.https://ijns.sums.ac.ir/article_44985_04c9c796aaae74f31e66d8f635d0a44f.pdfShiraz University of Medical SciencesInternational Journal of Nutrition Sciences2538-18734220190601The Relation between Dietary Components and Body Mass Index with Urinary Prostaglandin E2 Level in 5-15 Years Children with Nocturnal Enuresis78824498610.30476/ijns.2019.81826.1015ENElhamRahmaniDepartment of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IranNutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IranMohammad HassanEftekhariDepartment of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IranNutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran0000-0001-5428-1491Mohammad HassanFallahzadehDepartment of Pediatric Nephrology, Faculty of Medicine, Shiraz University of Medical Sciences,Shiraz, IranMohammadFararueiDepartment of Epidemiology, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, IranJournal Article20180213Background: Nocturnal enuresis is known as a common urinary bladder complication in children. Recent studies associated some dietary components with nocturnal enuresis. To our knowledge, no study has designed to evaluate the relation between dietary components with urinary prostaglandin E2 in enuretic children.<br />Methods: In this cross-sectional study, we enrolled 135 children with nocturnal enuresis from children who referred to pediatric ward of Imam Reza Clinic in Shiraz, Iran. The samples were selected by the multistage cluster random sampling. Participant`s information (age, sex, number of wet-nights/week) were gathered through interview and body mass index (BMI) and waist-tohip ratio (WHR) were assessed through anthropometric measures also dietary fat, calcium, calorie, vitamin B12, folic acid, iron and some foods usually limited for enuretic children (e.g. milk and dairy products, eggs, citrus fruits and juices, tomatoes, chocolate) and carbonated beverages were measured through validated food frequency questionnaire (FFQ). Fasting urine was also collected for measuring prostaglandin E2 level.<br />Results: Our study showed that food components and energy intake were not correlated with urinary PGE2. Participants’ BMI and WHR were moderately correlated with PGE2 which were not significant. Of allergic foods, only cheese had significant correlation with urinary PGE2.<br />Conclusion: There were no significant correlations between dietary components and BMI and urinary prostaglandin E2. Cheese consumption caused lower PGE2 level probably by decreasing omega6 especially arachidonic acid level.https://ijns.sums.ac.ir/article_44986_f83b2824750c706e3d0efb2a2f48a7cc.pdfShiraz University of Medical SciencesInternational Journal of Nutrition Sciences2538-18734220190601The Effect of Aqueous Extract of Berberis Vulgaris on Fetal Height and Weight during Pregnancy83874533810.30476/ijns.2019.82444.1020ENDavoodMehrabaniStem cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, IranBurn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, IranComparative and Experimental Medicine Center, Shiraz University of Medical Sciences, Shiraz, IranMahbobeZabetiScience and Research Branch, Islamic Azad University, Fars, IranAkbarVahdatiScience and Research Branch, Islamic Azad University, Fars, IranMehdiPasalarTraditional Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran00000000000000000000MinaRabieeShahreKord Branch, Islamic Azad University, ShahreKord, Iran0000-0002-7275-3365Seyed JalilMassoumiNutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran0000-0001-6712-6802Journal Article20180103Background: Nowadays, the use of herbal medicine for the treatment of different diseases especially during pregnancy is increasing. It was shown that some herbs have irreparable effects on fetal development and on pregnancy. The aim of this study was to investigate the effect of aqueous extract of Berberis vulgaris on fetal height and weight during pregnancy.<br /> Methods: In this experimental study, one-hundred and twenty adult female mice were enrolled. After confirmation of pregnancy, they were divided to four groups evaluated during first, second and third week of pregnancy. The control group mice were pregnant without any intervention. The second, third and fourth group received 2000, 3500 and 5000 mg/kg of barberry, respectively. The fetal weight and height were measured in each group and compared.<br /> Results: In the first, second and third week of gestation, 5000 mg/kg of barberry decreased the embryo’s weight and height in comparison to other groups.<br /> Conclusion: The high dose of barberry resulted in adverse effects on fetal growth<br /> especially in the last week of pregnancy. Therefore, it should be administered with caution during gestation period.https://ijns.sums.ac.ir/article_45338_b0b1bac84e7584272bbd72cc202b7e0a.pdfShiraz University of Medical SciencesInternational Journal of Nutrition Sciences2538-18734220190601The Effect of Simultaneous Consumption of Coffee Caffeine and Sleep Deprivation on Plasma Ghrelin and Leptin Levels88964538510.30476/ijns.2019.82136.1017ENBehrouzRasaeiNutritional Sciences Programme, School of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia00000000000000000000NorimahAbdul KarimNutritional Sciences Programme, School of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia00000000000000000000RuzitaAbd TalibNutritional Sciences Programme, School of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia00000000000000000000IsmailMohd NoorSchool of Hospitality, Tourism and Culinary Arts, Taylors University, Selangor, Malaysia00000000000000000000MajidKarandishNutrition and Metabolic Diseases Research Center, Ahvaz Jundishpur Univerity of Medical Sciences, Ahvaz, Iran00000000000000000000Journal Article20181008Background: Unlike sleep deprivation, caffeine in coffee has been shown to yield positive effects on appetite, body weight, and risk of developing symptoms of metabolic syndrome. However, the combined effects of caffeinated coffee and sleep deprivation are unknown. The aim of this study was to determine the simultaneous effects of coffee caffeine intake and sleep deprivation on leptin and ghrelin.<br />Methods: This was a randomized clinical trial comprised three-day treatments with two-week washout interval. Forty-two healthy men, habitual caffeinated coffee consumers (1-3 cups/day) and good sleepers (based on the Pittsburgh Sleep Quality Index) were recruited. Subjects were randomly assigned to three groups: three nights of deprived sleep (4 hrs. in bed) plus 3×150 mL/cup of boiled water (BW treatment), decaffeinated coffee (DC treatment, without sugar, 99.9% caffeine-free), and caffeinated coffee (CC treatment, without sugar, 65 mg caffeine/cup). DC and CC treatments were blinded. At the end, fasting serum leptin and plasma ghrelin were measured and compared.<br />Results: No significant differences were found between the treatments in the leptin level but a significant difference was shown between the treatments in plasma ghrelin (P=0.048). Pairwise comparisons test<br />showed that the CC treatment led to lower plasma ghrelin as compared to the DC treatment (P=0.006).<br />Conclusion: Caffeinated coffee with sleep deprivation simultaneously manipulated the level of ghrelin towards an anorexigenic effect (reduced plasma ghrelin). However, further investigations are required to support<br />caffeinated coffee as an appetite/weight loss recommendation.https://ijns.sums.ac.ir/article_45385_04711210e0266c4921137c4e2bd27348.pdfShiraz University of Medical SciencesInternational Journal of Nutrition Sciences2538-18734220190501The Role of Seaweed Concentration Gracilaria Sp with Response Surface Methodology on Optimization of Analog Rice Formulation971034531310.30476/ijns.2019.81554.1010ENLegoSuhonoFisheries Product Processing Engineering, Marine and Fisheries Polytechnic Sidoarjo, Indonesia0000-0003-3759-6496SriRumiyatiFisheries Product Processing Engineering, Marine and Fisheries Polytechnic Sidoarjo, Indonesia0000-0002-3206-1647EndangTrowulanFisheries Product Processing Engineering, Marine and Fisheries Polytechnic Sidoarjo, IndonesiaMasirahMasirahFisheries Product Processing Engineering, Marine and Fisheries Polytechnic Sidoarjo, IndonesiaJournal Article20190103Background: Indonesia has potential to be the biggest seaweed exporter in the world due to its fisheries potential. Brackish ponds are not merely used for cultivating fish and shrimp, but it is also used for seaweed cultivation. Thus, this study aimed to produce an innovative product that is staple food from Gracilaria Sp seaweed into analog rice, which can support pond formers in Sidoarjo.<br />Methods: In this experimental study, optimization of analog rice process from Gracilaria used Response Surface Methodology with various Gracilaria seaweed concentration (X1%) third levels (60%, 65%, 70%). However, parameter response that has been observed is iodine level (Y1 ppm), food fiber level (Y2%), yield (Y3%), aroma value (Y4), taste value (Y5), and texture level (Y6).<br />Results: According to the organoleptic test, analog rice from Gracilaria seaweed which composed of 65.84% seaweed, modified cassava flour 31.16%, and vegetable oil and glycerin 3% had optimum way of taste, aroma, and texture. Food fiber of seaweed composition (65%), modified cassava flour (32%), and vegetable oil as well as glycerin (3%) was 2.39% bigger than rice food fiber standard (1.3%). The iodine composition in the form of analog rice from Gracilaria seaweed was 74.55 ppm (74550μg) more than the average standard of human iodine needs of 150 μg/day.<br />Conclusion: Anolog rice made from Gracilaria Sp had good quality to consume.https://ijns.sums.ac.ir/article_45313_af54366958f6d34c869b049c92540ec8.pdf