The Effect of Banana (Musa nana Lour.) Peel Extract and Omega-3 on Biochemical and Histopathological Characteritics in Rat Model of Polycystic Ovary Syndrome

Document Type : Original Article

Authors

1 Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran

2 Henan Key Laboratory of Environmental and Animal Product Safety, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan, China

3 Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

4 Department of Toxicology and Pharmacology, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran

5 Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran

10.30476/ijns.2025.101331.1297

Abstract

Background: In women of reproductive age, polycystic ovary syndrome (PCOS) is a prevalent endocrine condition. This study assessed the effect of banana (Musa nana Lour.) peel extract and omega-3 on biochemical and histopathological features in rat model of PCOS.
Methods: After PCOS induction, 56 adult female rats were randomly divided into seven groups. In group 1, healthy rats were given 20 mg/kg/day of normal saline. Group 2 comprised PCOS rats receiving saline as 20 mg/kg/day. Group 3 included rats with PCOS receiving 240 mg/kg/day omega-3. Group 4 consisted of rats with PCOS receiving 6
mL/kg/day of banana peel extract. Group 5 contained rats with PCOS receiving 12 mL/kg/day banana peel extract. Group 6 enrolled rats with PCOS taking 240 mg/kg/day omega-3 and 12 mL/kg/day banana peel extract. Group 7 consisted of rats with PCOS treated with 200 mg/kg/day metformin. Serum biochemical parameters and ovarian oxidative stress were evaluated together with histological assessment. The duration of treatment for all groups was 8 weeks.
Results: Glycemic indices, serum triglyceride level, serum testosterone concentration, oxidative stress, and body weight significantly decreased. The ovarian tissue pathology in the animals treated with banana peel extract and omega-3 in comparison to the PCOS control group showed an improvement (p<0.05).
Conclusion: Omega-3 supplementation with banana peel extract as an antioxidant may have beneficial effects on biochemical parameters and pathological demonstrations of PCOS.

Highlights

Najmeh Hejazi (Google Scholar)

Keywords

Main Subjects

Files

Share

How to cite

Statistics