The Relation between Dietary Components and Body Mass Index with Urinary Prostaglandin E2 Level in 5-15 Years Children with Nocturnal Enuresis

Document Type : Original Article


1 Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran

2 Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran

3 Department of Pediatric Nephrology, Faculty of Medicine, Shiraz University of Medical Sciences,Shiraz, Iran

4 Department of Epidemiology, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran


Background: Nocturnal enuresis is known as a common urinary bladder complication in children. Recent studies associated some dietary components with nocturnal enuresis. To our knowledge, no study has designed to evaluate the relation between dietary components with urinary prostaglandin E2 in enuretic children.
Methods: In this cross-sectional study, we enrolled 135 children with nocturnal enuresis from children who referred to pediatric ward of Imam Reza Clinic in Shiraz, Iran. The samples were selected by the multistage cluster random sampling. Participant`s information (age, sex, number of wet-nights/week) were gathered through interview and body mass index (BMI) and waist-tohip ratio (WHR) were assessed through anthropometric measures also dietary fat, calcium, calorie, vitamin B12, folic acid, iron and some foods usually limited for enuretic children (e.g. milk and dairy products, eggs, citrus fruits and juices, tomatoes, chocolate) and carbonated beverages were measured through validated food frequency questionnaire (FFQ). Fasting urine was also collected for measuring prostaglandin E2 level.
Results: Our study showed that food components and energy intake were not correlated with urinary PGE2. Participants’ BMI and WHR were moderately correlated with PGE2 which were not significant. Of allergic foods, only cheese had significant correlation with urinary PGE2.
Conclusion: There were no significant correlations between dietary components and BMI and urinary prostaglandin E2. Cheese consumption caused lower PGE2 level probably by decreasing omega6 especially arachidonic acid level.