The Effects of Papaya Fruit as Anti Diabetes: A Review

Document Type : Review Article


1 Department of Clinical Nutrition and Nutrition Sciences, Postgraduate Sebelas Maret University, Surakarta, Indonesia

2 Department of Clinical Pathology, Faculty of Medicine Sebelas Maret University, Surakarta, Indonesia

3 Department of Nutrition, Faculty of Medicine Sebelas Maret University, Surakarta, Indonesia


Diabetes mellitus (DM) is a disease that results in an imbalance in the body ability to use food efficiently caused by the pancreas failure to produce insulin or dysfunction of the body to use insulin properly. Type 2 DM can cause oxidative stress which results in changes in endogenous antioxidant activity and also an increase in oxidative biomolecular damage. This condition causes patients with type 2 DM to require large amounts of exogenous antioxidant intake to inhibit oxidative damage in the body. One of the medicinal plants that has antihyperglycemic activity and high antioxidants is papaya (Carica papaya Linn). Based on a review of several studies noted that papaya contains vitamin C, fiber saponins and flavonoids that can lower blood glucose levels. However, to prove this effect, further clinical trials are needed to be done.