The Effect of Aerobic Training and Coriander Seed on Oxidative Stress and Mitochondrial Function Markers in Lung Tissue of Rats Exposed to H2O2

Mardani, Zahra; Hosseini, Seyed Ali; Matinhomaee, Hassan; Rahmati-Ahmadabad, Saleh

doi:10.30476/ijns.2021.91492.1139

The Effect of Aerobic Training and Coriander Seed on Oxidative Stress and Mitochondrial Function Markers in Lung Tissue of Rats Exposed to H2O2

Document Type : Original Article

Authors

Zahra Mardani ¹

Seyed Ali Hosseini ²

Hassan Matinhomaee ¹

Saleh Rahmati-Ahmadabad ³

¹ Department of Sports Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran

² Department of Sports Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran

³ Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, Iran

10.30476/ijns.2021.91492.1139

Abstract

Background: Exposure to hydrogen peroxide (H2O2) in addition to increase in the oxidative stress can alter mitochondrial function. The present study aimed to investigate the effect of training with coriander seed consumption on mitochondrial function and oxidative stress markers in the lung tissue of rats exposed to H2O2.
Methods: Thirty-five rats were divided into 7 groups, including (i) saline healthy control, (ii) saline toxic control, (iii) coriander toxic control (500 mg/kg), (iv) coriander toxic control (1000 mg/kg), (v) coriander toxic training (500 mg/kg), (vi) coriander toxic training (1000 mg/kg), and (vii) saline toxic training groups. During eight weeks, groups 2-7 received 1 mmol/kg H2O2 for three times per week and groups 5-7 performed training three sessions per week.
Results: Training and coriander significantly increased adenosine triphosphate (ATP) and decreased caspase-3, cytochrome-C, O-6- methylguanine-DNA methyltransferase (MGMT) and prealbumin (PAB) (p≤0.05). Also, interactive effects of training and coriander on increase of ATP and decrease of caspase-3, cytochrome-C, and PAB at a dose of 1000 mg/kg were higher than 500 mg/kg (p≤0.05).
Conclusion: Although training and coriander alone could enhance the mitochondrial function and oxidative stress markers, training simultaneously with coriander had more favorable effects compared to each one alone.

Keywords

Training

Coriander

Oxidative stress

Lung

H2O2