The Effect of Bariatric Surgery on Polycystic Ovary Syndrome (PCOS) Symptoms and Related Hormones Improvement in Women with Morbid Obesity

Document Type : Original Article


1 Department of Obstetrics and Gynecology, School of Medicine, Shahid Beheshti University Of Medical Sciences, Tehran, Iran

2 Laparascopy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

3 Iranian Hospital Dubai, Iranian Red Crescent Society, Dubai, United Arab Emirates

4 Department of surgery, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

5 Laparoscopy Research Center, Shiraz University of medical sciences, Shiraz, Iran


Background: Obesity is associated with developing polycystic ovary syndrome (PCOS). The present study investigated whether weight loss after bariatric surgery could improve symptoms and related hormones in women with morbid obesity.
Methods: In a retrospective observational study, 50 women aged 18-40 years with body mass index (BMI)=42.3 kg/m2 who underwent laparoscopic Roux-en-Y gastric bypass (RYGB) were enrolled. Evaluation of anthropometric data, serum testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), fasting plasma
glucose (FPG), and lipid profile were measured preoperatively and at 1-year follow-up
Results: Of 50 women, 32 (64%) women were diagnosed to have PCOS. The mean BMI at 1-year follow-up was 27.05 kg/m2. Hirsutism and irregular menstruation resolved entirely among 68.8% (11/16) and 100% (18/18) at 1-year follow-up. There was a significant decrease in total serum testosterone (2.1±0.2 to 0.9±0.1 ng/mL) and LH (8.5±3.36 to 5.02±2.4 mIU/mL) at 1-year follow-up, whether changes in levels of serum FSH, PRL were not significant.
Conclusion: Bariatric surgery was effective in weight loss and improvement of PCOS symptoms and related hormones in women with morbid obesity. Thus, women with PCOS and morbid obesity should be eligible for bariatric surgery.


Neda Haghighat (Google Scholar)


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