Document Type : Original Article
Authors
1
Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran
2
Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran
3
Department of Nutrition Sciences, Varastegan Institude for Medical Sciences, Mashhad Iran
4
Cardiovascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
5
Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
6
Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad Iran
7
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
8
Brighton and Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK
9
International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
10
Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
11
Biochemistry & Nutrition Research Center, Cardiovascular Research Centre, Avicenna (Bu-Ali) Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
10.30476/ijns.2025.104928.1374
Abstract
Background: Obesity has been managed using different treatments including cryolipolysis; while a relationship was reported between obesity and mental disorders too. This study aimed to assess the effect of low caloric diet plus cryolipolysis on depression and anxiety in comparison to low caloric diet alone in overweight subjects.
Methods: In a randomized controlled clinical trial, 50 healthy overweight females (25 kg/m2≤ body mass index (BMI)<30 kg/m2) aged 18 to 65 years were recruited in this study. Subjects were randomly allocated to two groups who received a calorie restricted diet with and without cryolipolysis. Anthropometrics and serum biochemistry tests were undertaken to measure the baseline and the end of the study (8th week). Depression and anxiety were assessed using the body shape questionnaire (BSQ), Beck’s depression inventory (BDI) and Beck Anxiety Index (BAI) tests at the beginning and the end of study.
Results: All participants completed the study period. A significant difference was found in the BSQ at the baseline and the end of study between the intervention and control groups (9.96±18.61 vs. -19.24±26.55, respectively, p<0.001). A significant difference was found in BAI (-3.52±7.63 vs. 1.08±7.01, respectively, p=0.031) between the two groups. BDI changes between the two groups did not differ significantly (p>0.05).
Conclusion: Cryolipolysis was demonstrated to improve the anxiety in overweight subjects. The molecular mechanism is not clear yet and further studies with a large sample size are necessary to be investigated.
Keywords
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