Document Type : Original Article
Authors
1
Interventional Cardiology Research Center, Rajaie Cardiovascular Medical Research Center, Tehran, Iran
2
Pharmaceutical Science Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
3
GI Pharmacology Interest Group, Universal Scientific Education and Research Network, Tehran, Iran
4
Student Research Committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5
Department of Surgery, Arak University of Medical Sciences, Arak, Iran
6
Department of Neurology, Kermanshah University of Medical Sciences, Kermanshah
10.30476/ijns.2025.104935.1375
Abstract
Background: Diabetes Mellitus (DM) is a metabolic disorder that leads to an abnormal glucose level. The goal of this study was to examine the impact of ghee on lipid profile, liver enzymes, and glucose, urea and creatinine levels in diabetic and healthy rats.
Methods: Forty eight male Wistar rats were categorized into six equal groups including a diabetic control group, diabetic groups receiving 4 and 8 mg of ghee, a healthy control group, and healthy groups receiving 4 and 8 mg of ghee. Blood, liver, and pancreas samples were provided and investigated for these variables after three months of interventions.
Results: Ghee could significantly increase the glucose level in healthy rats (p=0.0001); but decreased the glucose level in diabetic rats (p=0.001 for 4 mg/kg and p=0.0001 for 8 mg/kg). Cholesterol level was significantly lower in diabetic rats treated with ghee (p=0.0001 for 4 mg/kg and p=0.048 for 8 mg/kg). Triglyceride level and liver enzymes exhibited a dose dependent change and an enhanced kidney function in diabetic rats.
Conclusion: Ghee administration resulted in a reduction in blood glucose level, improvement in lipid profile, and an enhanced kidney function in diabetic rats. Notably, a significant difference was observed between the doses of 4 mg/kg and 8 mg/kg of ghee, with an increasing effect that was dose dependent. However, in healthy rats, ghee led to an elevation in blood sugar level in a dose-dependent manner.
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