The Relationship between High-Protein Diets and Sarcopenia among Iranian Elderly Population

Document Type : Original Article

Authors

1 Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Department of Nutrition, Faculty of Health and Nutrition, Bushehr University of Medical Sciences, Bushehr, Iran

3 Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

4 Department of Nutrition and Biochemistry, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran

5 Department of Community Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran

6 Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran

7 Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract

Background: Nutrition is crucial for boosting the performance, muscular power, and size of older adults. The current research’s objective was to explore the link between the risk of sarcopenia and a high-protein diet score among Iranian elderly population.
Methods: Two groups of a case group of 80 elderly individuals and a control group of 80 elderly subjects aged 65 years or older in Iran were enrolled. The recommendations of the Asian Working Group for Sarcopenia were applied to diagnose sarcopenia. To assess dietary intake, a food frequency questionnaire with 168 items was applied. There were three distinct kinds of high-protein diets created. Using logistic regression, the link between the risk of sarcopenia and high-protein diet scores was analyzed.
Results: Each point rise in all high-protein diet scores (low-carbo, low-fat, and high-protein diet [odds ratio (OR)=0.638, 95% confidence interval (95%CI): 0.551-0.739; low-fat, high-carb, and high-protein diet: OR=0.856, 95%CI: 0.813-0.902; high-fat, low-carb, and high-protein diet: OR=0.828, 95%CI: 0.757-0.907)] was linked to a lower chance of developing sarcopenia in the crude model. However, in the adjusted models, no association was identified between and all high-protein diet scores and sarcopenia odds.
Conclusion: The current case-control study did not find any significant correlation between high-protein dietary intake and the risk of sarcopenia.

Highlights

Mohammad Hossein Dabbaghmanesh (Google Scholar)

Keywords

References

  1. Cruz-Jentoft AJ, Sayer AA. Sarcopenia. Lancet. 2019;393:2636-46. DOI: 10.1016/S0140-6736(19)31138-9. PMID: 31171417.
  2. Morley J. Sarcopenia: diagnosis and treatment. J Nutr Health Aging. 2008;12:452-6. DOI: 10.1007/BF02982705. PMID: 18615226.
  3. Petermann-Rocha F, Chen M, Gray SR, et al. Factors associated with sarcopenia: A cross-sectional analysis using UK Biobank. Maturitas. 2020;133:60-7. DOI: 10.1016/j.maturitas.2020.01.004. PMID: 32005425.
  4. Wakimoto P, Block G. Dietary intake, dietary patterns, and changes with age: an epidemiological perspective. J Gerontol A Biol Sci Med Sci. 2001;56:65-80. DOI: 10.1093/gerona/56.suppl_2.65. PMID: 11730239.
  5. Agarwal E, Miller M, Yaxley A, et al. Malnutrition in the elderly: a narrative review. Maturitas. 2013;76:296-302. DOI: 10.1016/j.maturitas.2013.07.013. PMID: 23958435.
  6. Andisheh-Tadbir A, Mehrabani D, Heydari St. Sociodemographic And Etiological Differences Of Head And Neck Squamous Cell Carcinoma In Young And Old Patients In Southern Iran. J Craniofac Surg. 2010;21:126-8. DOI: 10.1097/SCS.0b013e3181c46c10. PMID: 20072017.
  7. Robinson SM, Reginster JY, Rizzoli R, et al. Does nutrition play a role in the prevention and management of sarcopenia? Clin Nutr. 2018;37:1121-32. DOI: 10.1016/j.clnu.2017.08.016. PMID: 28927897.
  8. Mehrabani D, Masoumi SJ, Masoumi AS, et al. Role of diet in mesenchymal stem cells’ function: a review. Int J Nutr Sci. 2023;8:9-19. DOI: 10.30476/IJNS.2023.97788.1221.
  9. Calvani R, Miccheli A, Landi F, et al. Current nutritional recommendations and novel dietary strategies to manage sarcopenia. J Frailty Aging. 2013;2:38-53. PMID: 26082911.
  10. Chen LK, Arai H, Assantachai P, et al. Roles of nutrition in muscle health of community‐dwelling older adults: evidence‐based expert consensus from Asian Working Group for Sarcopenia. J Cachexia Sarcopenia Muscle. 2022;13:1653-72. DOI: 10.1002/jcsm.12981. PMID: 35307982.
  11. Ziaaldini MM, Marzetti E, Picca A, et al. Biochemical pathways of sarcopenia and their modulation by physical exercise: a narrative review. Front Med. 2017;4:167. DOI: 10.3389/fmed.2017.00167. PMID: 29046874.
  12. Coelho-Junior HJ, Calvani R, Azzolino D, et al. Protein intake and sarcopenia in older adults: a systematic review and meta-analysis. Int J Environ Res Public Health. 2022;19:8718. DOI: 10.3390/ijerph19148718. PMID: 35886571.
  13. Beasley JM, Shikany JM, Thomson CA. The role of dietary protein intake in the prevention of sarcopenia of aging. Nutr Clin Pract. 2013;28:684-90. DOI: 10.1177/0884533613507607. PMID: 24163319.
  14. Homayoun M, Mehrabani D, Edalatmanesh MA, et al. The Role of Lithium Chloride in Nutrition and Stem Cell Growth Kinetics: A Review. Int J Nutr Sci. 2021;6:6-13. DOI: 10.30476/IJNS.2021.88801.1104.
  15. Nowson C, O’Connell S. Protein requirements and recommendations for older people: a review. Nutrients. 2015;7:6874-99. DOI: 10.3390/nu7085311. PMID: 26287239.
  16. Deutz NE, Bauer JM, Barazzoni R, et al. Protein intake and exercise for optimal muscle function with aging: recommendations from the ESPEN Expert Group. Clin Nutr. 2014;33:929-36. DOI: 10.1016/j.clnu.2014.04.007. PMID: 24814383.
  17. Gorissen SH, Witard OC. Characterising the muscle anabolic potential of dairy, meat and plant-based protein sources in older adults. Proc Nutr Soc. 2018;77:20-31. DOI: 10.1017/S002966511700194X. PMID: 28847314.
  18. Mahmoodi R, Daryanoosh F, Kasharafifard S, et al. Effect of exercise on serum adiponectin and lipoprotein levels in male rat. Pak J Biol Sci. 2014;17:297-300. DOI: 10.3923/pjbs.2014.297.300. PMID: 24783818.
  19. Stoodley IL, Williams LM, Wood LG. Effects of Plant-Based Protein Interventions, with and without an Exercise Component, on Body Composition, Strength and Physical Function in Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2023;15:4060. DOI: 10.3390/nu15184060. PMID: 37764843.
  20. Daryanoosh F, Sharifi GR, Jafari M, et al. The effect of running exercise and calcium supplementation on femoral bone strength in ovariectomized rats. Global Vet. 2013;11:694-700. DOI: 10.5829/idosi.gv.2013.11.6.81189.
  21. Lim MT, Pan BJ, Toh DWK, et al. Animal protein versus plant protein in supporting lean mass and muscle strength: a systematic review and meta-analysis of randomized controlled trials. Nutrients. 2021;13:661. DOI: 10.3390/nu13020661. PMID: 33670701.
  22. Gazzani D, Zamboni F, Spelta F, et al. Vegetable but not animal protein intake is associated to a better physical performance: A study on a general population sample of adults. Food Nutr Res. 2019;63. DOI: 10.29219/fnr.v63.3422. PMID: 31565042.
  23. Roubenoff R. Sarcopenia and its implications for the elderly. Eur J Clin Nutr. 2000;54:S40-S7. DOI: 10.1038/sj.ejcn.1601024. PMID: 11041074.
  24. Nasimi N, Dabbaghmanesh MH, Sohrabi Z. Nutritional status and body fat mass: Determinants of sarcopenia in community-dwelling older adults. Expe Gerontol. 2019;122:67-73. DOI: 10.1016/j.exger.2019.04.009. PMID: 31022445.
  25. Moghaddam MB, Aghdam FB, Jafarabadi MA, et al. The Iranian Version of International Physical Activity Questionnaire (IPAQ) in Iran: content and construct validity, factor structure, internal consistency and stability. World Appl Sci J. 2012;18:1073-80. DOI: 10.5829/idosi.wasj.2012.18.08.754.
  26. Chen LK, Liu LK, Woo J, et al. Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc. 2014;15:95-101. DOI: 10.1016/j.jamda.2013.11.025. PMID: 24461239.
  27. Mirmiran P, Esfahani FH, Mehrabi Y, et al. Reliability and relative validity of an FFQ for nutrients in the Tehran lipid and glucose study. Public Health Nutr. 2010;13:654-62. DOI: 10.1017/S1368980009991698. PMID: 19807937.
  28. Ghaffarpour M, Houshiar-Rad A, Kianfar H. The manual for household measures, cooking yields factors and edible portion of foods. Tehran: Nashre Olume Keshavarzy. 1999;7:42-58.
  29. Nutritionist I. N-squared computing. Silverton: Nutritionist IV. 1998.
  30. Granic A, Mendonça N, Sayer AA, et al. Effects of dietary patterns and low protein intake on sarcopenia risk in the very old: The Newcastle 85+ study. Clin Nutr. 2020;39:166-73. DOI: 10.1016/j.clnu.2019.01.009. PMID: 30709690.
  31. Verlaan S, Aspray TJ, Bauer JM, et al. Nutritional status, body composition, and quality of life in community-dwelling sarcopenic and non-sarcopenic older adults: A case-control study. Clin Nutr. 2017;36:267-74. DOI: 10.1016/j.clnu.2015.11.013. PMID: 26689868.
  32. Rahman R, Wilson BP, Paul TV, et al. Prevalence and factors contributing to primary sarcopenia in relatively healthy older Indians attending the outpatient department in a tertiary care hospital: A cross-sectional study. Aging Med (Milton). 2021;4:257-65. DOI: 10.1002/agm2.12186. PMID: 34964006.
  33. Montiel-Rojas D, Nilsson A, Santoro A, et al. Fighting Sarcopenia in Ageing European Adults: The Importance of the Amount and Source of Dietary Proteins. Nutrients. 2020;12:3601. DOI: 10.3390/nu12123601. PMID: 33255223.
  34. Houston DK, Nicklas BJ, Ding J, et al. Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr. 2008;87:150-5. DOI: 10.1093/ajcn/87.1.150. PMID: 18175749.
  35. Scott D, Blizzard L, Fell J, et al. Associations between dietary nutrient intake and muscle mass and strength in community-dwelling older adults: the Tasmanian Older Adult Cohort Study. J Am Geriatr Soc. 2010;58:2129-34. DOI: 10.1111/j.1532-5415.2010.03147.x. PMID: 21054294.
  36. Houston DK, Nicklas BJ, Ding J, et al. Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr. 2008;87:150-5. DOI: 10.1093/ajcn/87.1.150. PMID: 18175749.
  37. Campbell WW, Trappe TA, Wolfe RR, et al. The recommended dietary allowance for protein may not be adequate for older people to maintain skeletal muscle. J Gerontol A Biol Sci Med Sci. 2001;56:M373-80. DOI: 10.1093/gerona/56.6.m373. PMID: 11382798.
  38. Reid-McCann RJ, Brennan SF, McKinley MC, et al. The effect of animal versus plant protein on muscle mass, muscle strength, physical performance and sarcopenia in adults: protocol for a systematic review. Syst Rev. 2022;11:64. DOI: 10.1186/s13643-022-01951-2. PMID: 35418173.
  39. Lewallen S, Courtright P. Epidemiology in practice: case-control studies. Community Eye Health. 1998;11:57-8. PMID: 17492047.
  40. Tenny S, Kerndt CC, Hoffman MR. Case Control Studies. StatPearls. Treasure Island (FL): StatPearls Publishing Copyright © 2024, StatPearls Publishing LLC.; 2024. PMID: 28846237.

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