Analysis of Insulin Resistance Markers and Lipid Profile in Patients in Baghdad, Iraq

Document Type : Original Article

Authors

Department of Physiology, College of Medicine/ University of Baghdad, Baghdad, Iraq

10.30476/ijns.2026.106159.1429

Abstract

Background: Insulin resistance (IR) is a detrimental common condition related to type 2 diabetes mellitus and different metabolic diseases. The common indices are the homeostasis model assessment of insulin resistance (HOMA-IR) and triglyceride glucose (TyG) index. This study analyzed IR markers and lipid profile in patients in Baghdad, Iraq.
Methods: A cross-sectional study from March 7 2024 to June 1st 2024 was performed at Nutrition and Obesity Center in Al-Kindy Hospital, Baghdad, Iraq enrolling 100 participants (81 females and 19 males) aged between 18-60 years. They were categorized into obese and non-obese groups based on their BMI values. BMI, fasting blood glucose, fasting insulin and lipid profile (total cholesterol, triglycerides, LDL-C, and HDL-C) and HbA1C were determined and analyzed.
Results: HOMA-IR index detected 38% of IR individuals, while TyG index verified 51%. BMI was shown to be correlated too (p=0.0001, p=0.033, respectively). For lipid profile, LDL-C and total cholesterol were inversely related to HOMA-IR index (p=0.048, p=0.163, respectively). HDL-C had inverse relationship with HOMA-IR (p=0.014), and triglyceride had a positive correlation with HOMA-IR (p=0.190). TyG revealed a positive correlation with total cholesterol and triglyceride (p=0.0006, p=0.0001, respectively). The correlation between TyG index and LDL was positive, and forTyG and HDL was negative (p=0.105, p=0.179, respectively).
Conclusion: TyG index was superior to HOMA-IR with a stronger positive correlation to the BMI marker too. Lipid profile revealed a weak relationship with HOMA-IR ant TyG indices.

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