Anti-Inflammatory Effect of Acetylcysteine and Royal Jelly against Fluoxetine-Induced Hepatotoxicity in Rats

Document Type : Original Article

Authors

1 Ministry of Health, Thi Qar Health Directorate, Al Hussain Teaching Hospital, Thi Qar, Iraq

2 Department of Pharmacology and Toxicology, College of Pharmacy, University of Basrah, Basrah, Iraq

10.30476/ijns.2026.106743.1463

Abstract

Background: Hepatic toxicity of antipsychotic drugs needs to be protected by hepatoprotective medications. This study evaluated the antiinflammatory effect of N-acetylcysteine (NAC) and Royal jelly against hepatotoxicity of fluoxetine in rats.
Methods: Thirty adult female rats were divided into five equal groups of 6 rats. Group A was considered negative control. Group B were rats administered orally by fluoxetine (10 mg\kg) to induce hepatotoxicity. Group C were animals pre-treated with oral NAC (200 mg\kg) and then fluoxetine (10 mg\kg). Group D was pre-treated with Royal jelly (150 mg\kg) following the use of fluoxetine (10 mg\kg). Group E was pretreated with oral Royal jelly and NAC following fluoxetine utilization. After completion of 28 days of treatment, the rats were euthanized and a blood sample was collected and evaluated for inflammatory cytokines of tumor necrotizing factor alpha (TNF-α), interleukin-10 (IL10) and oxidative stress biomarkers of malondialdehyde (MDA) and glutathione (GSH) by ELISA.
Results: Fluoxetine induced hepatotoxicity and an increase in inflammatory cytokines such as TNF-α. Royal jelly and NAC showed significant anti-inflammatory and antioxidant effects by reduction in inflammatory cytokines and oxidative parameters.
Conclusion: Both NAC and Royall jelly were shown to have antioxidant and anti-inflammatory activities, even NAC impact was more than Royal jelly against hepato toxicity induced by fluoxetine. 

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