Development of an Anti-inflammatory Oral Nutrition Supplement Formula in Critically Ill Patients Admitted to Intensive Care Unit: A Double Blind Randomized Protocol Study

Articles in Press

Document Type : Original Article

Authors

1 Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2 Department of Nutrition, Varastegan Institute for Medical Sciences, Mashhad, Iran

3 Service of Intensive Care Medicine, Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

4 Cancer Prevention and Control Program, University of South Carolina, Columbia, South Carolina, USA

5 Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA

6 Department of Medical Informatics, Mashhad University of Medical Sciences, Mashhad, Iran

7 Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

8 Assistant professor in the Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

10.30476/ijns.2026.106604.1453

Abstract

Background: Critical illnesses such as sepsis and acute respiratory distress syndrome (ARDS) can lead to organ dysfunction and high mortality and present significant challenges in in intensive care units (ICUs). Current research highlights the importance of nutritional support in managing inflammation and immune response. This study developed a novel anti-inflammatory formula targeting inflammatory markers in ICU
patients.
Methods: Seventy-four critically ill adult patients were randomly divided into two groups within 24-48 hours of ICU admission. Two treatment interventions were used; while the control group received the standard oral nutritional supplement (ONS) formula as two times gavage meal, and the intervention group received an anti-inflammatory formula with a low inflammatory profile in the same way as control group for 14 days. Data collection were included demographic information and blood samples at baseline, day 7, and day 14.
Results: Nutritional intervention in modulating inflammation and immune response in critically ill patients, particularly those experiencing systemic inflammatory response syndrome (SIRS) or sepsis was verified.
Conclusion: This study considering the efficacy of low inflammatory index formulas and their effects on clinical outcomes in critically ill trauma patients.

Highlights

Sajedeh Jandari (Google Scholar)

Reza Rezvani (Google Scholar)

Keywords

References

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International Journal of Nutrition Sciences

Articles in Press, Accepted Manuscript
Available Online from 23 August 2026

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