The Impact of Food Vitamins and Minerals on Proliferation, Differentiation, Homeostasis and Regenerative Capacity of Body Mesenchymal Stem Cells: A Narrative Review

Articles in Press

Document Type : Review Article

Authors

1 Comparative and Experimental Medicine Center, Shiraz University of Medical Sciences, Shiraz, Iran

2 Hamzavi Dental Clinic, Shiraz, Iran

3 Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran

4 School of Dentistry, Islamic Azad University, Shiraz Branch, Shiraz, Iran

5 Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

6 Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

7 Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

8 Department of Biomedical and Tissue Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran

10.30476/ijns.2026.112948.1727

Abstract

Several lines of evidence confirmed the idea that stem cells are among the major players in orchestrating the response of our body to nutrients, mainly due to their crucial role in tissue homeostasis as dietary components and nutritional status can significantly impact stem cell survival and performance in human body and subsequently health status. This review concentrated on literature findings to determine the impact of food components on function, proliferation, differentiation, homeostasis, and regenerative capacity of body mesenchymal stem cells by searching related databases and focusing on related keywords from June 2000 to June 2026. Even many studies regarding the impact of vitamins and mineral components on proliferation, differentiation, homeostasis and regenerative capacity of body mesenchymal stem cells are in vitro and require in vivo validation; but the positive physiological effects of vitamins and minerals through several mechanisms in the literature reflect their pivotal role in regenerative medcicne. It seems that improving nutritional intake and biochemical status of key micronutrients (e.g. vitamins and minerals) can be supportive for the efficacy of MSCs in therapies and immune function and subsequently the recovery and clinical outcome of patients. A proper food intake can particularly target the enhancement of stem cell activity, epigenetic regulation, redox–inflammatory pathways and cellular metabolism. In this review, mitochondrial metabolic checkpoint regulating stem cell maintenance was highlighted. It was discussed how diet affects the metabolism of stem cells through the nutrient sensing pathways, thereby affecting stem cell fate decision and tissue regeneration.

Highlights

Davood Mehrabani (Google Scholar)

Keywords

References

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