Effects of Papaya (Carica papaya L.) as Anti- Hyperlipidemia: A Systematic Review

Document Type : Review Article


1 Postgraduate Program of Nutrition Science, Universitas Sebelas Maret, Surakarta, Indonesia

2 Department of Physiology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia

3 Department of Anatomical Pathology, Faculty of Medicine, Sebelas Maret University, Surakarta

4 Department of Nutrition, Faculty of Health Sciences, Institut Kesehatan Helvetia, Deli Serdang, Indonesia


Papaya (Carica papaya L) is one of the fruits that is easily found in Asian countries. Papaya has been studied to have good benefits in hyperlipidemia. Papaya contains fiber, vitamins A and C, alkaloids, saponins, and flavonoids which are with antihyperlipidemic properties. The objective of this research was to systematically review studies that
have probed into the effect of papaya on triglyceride, total cholesterol, and low-density lipoprotein in hyperlipidemia. This research was conducted to review the effect of papaya fruit as an anti-hyperlipidemic through searching scientific articles related to the topic. Article searches were conducted through Google Scholar, PubMed, and Science-Direct
article databases. The selection of articles in the systematic review according to the inclusion criteria was based on articles published from 2016 to 2021, enrolling animals or patients with hyperlipidemia. The experimental design, main outcomes such as triglycerides, total cholesterol, LDL-C, HDL-C and body weight (BW) were investigated. Totally, three articles were reviewed in full to discuss the effect of papaya fruit as antihyperlipidemia in a systematic review. The systematic reviewreported that administration of papaya juice could improve lipid profiles. The content of fiber, vitamins A and C and phytochemicals in papaya has the potential of anti-hyperlipidemia by improving lipid profile.